Rituximab infusion induces NK activation in lymphoma patients with the high-affinity CD16 polymorphism.

نویسندگان

  • Suresh Veeramani
  • Siao-Yi Wang
  • Christopher Dahle
  • Sue Blackwell
  • Laura Jacobus
  • Tina Knutson
  • Anna Button
  • Brian K Link
  • George J Weiner
چکیده

Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity involving FcγRIIIa (CD16) likely contributes to the clinical efficacy of rituximab. To assess the in vivo effects of CD16 polymorphisms on rituximab-induced NK activation, blood was evaluated before and 4 hours after initiation of the initial dose of rituximab in 21 lymphoma subjects. Rituximab induced NK activation and a drop in circulating NK-cell percentage in subjects with the high-affinity [158(VF/VV)] but not the low-affinity [158(FF)] CD16 polymorphism. There was no correlation between NK-cell activation or NK-cell percentage and polymorphisms in CD32A, C1q, or CH50. We conclude that NK activation occurs within 4 hours of rituximab infusion in subjects with the high-affinity CD16 polymorphism but not those with the low-affinity CD16 polymorphism. This finding may help explain the superior clinical outcome seen in the subset of high-affinity CD16 polymorphism lymphoma patients treated with single-agent rituximab.

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عنوان ژورنال:
  • Blood

دوره 118 12  شماره 

صفحات  -

تاریخ انتشار 2011